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Species: Mouse
Genes: APP
Mutations:APP V717F (Indiana)
Modification: APP: Transgenic
Disease Relevance: Alzheimer's Disease
Strain Name: N/A
Genetic Background: C57B6 x DBA2
Availability: Unknown
Elan Mice & Touchpads Driver Download Windows 7
Summary
Elan Mice & Touchpads Driver Downloads
The PDAPP mouse was first described in 1995 (Games et al., 1995) and is considered one of the earliest mouse models of Alzheimer's disease. From a young age this model exhibits cognitive deficits in a variety of tasks, including spatial working memory at four months as assessed by the Morris water maze (Hartman et al., 2005). Deficits in recognition memory follow at approximately six months of age, as assessed by novel object recognition (Dodart et al., 1999). Many of the cognitive deficits in this model present prior to plaque deposition, which occurs at approximately six months of age.
As originally described, these mice exhibit high human APP expression, greater than 10-fold higher than endogenous murine APP. Because the construct allows for alternative splicing, multiple isoforms are produced including APP 695, 751 and 770. These mice exhibit extracellular Aβ deposition, dystrophic neurites, gliosis, and loss of synaptic and dendritic density in the hippocampus (Games et al., 1995).
Modification Details
A PDGF-driven human APP minigene with the V717F (Indiana) mutation. The construct contained APP introns 6-8 allowing alternative splicing of exons 7 and 8. Ghi usb devices driver download free.
Paper Citations
- .Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature. 1995 Feb 9;373(6514):523-7. PubMed.
- .Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. J Neurosci. 2005 Jun 29;25(26):6213-20. PubMed.
- .Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein. Behav Neurosci. 1999 Oct;113(5):982-90. PubMed.
Papers
Elan Mice & Touchpads Driver Download
- .Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. Front Genet. 2014;5:88. Epub 2014 Apr 23PubMed.
Elan Mice & Touchpads Driver Download 64-bit
- .Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature. 1995 Feb 9;373(6514):523-7. PubMed.
- .Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem. 1995 Nov 24;270(47):28257-67. PubMed.